prof-pradeepa jayawardane

RESEARCH & PUBLICATIONS


 

Prof.  Pradeepa Jayawardane

Prof. Pradeepa Jayawardane MBBS (Col), PhD (Peradeniya)

Professor in Pharmacology
Department of Pharmacology

Telephone - Office : +94 11 2758000 Ext: 4501     Mobile : +94 71 2304322
E-mail : pradeepajayawardane@yahoo.co.uk


 

RESEARCH EXPERIENCE


 

  • Antibiotic utilization patterns in the Teaching Hospitals in the Western Province Sri Lanka.
  • Epidemiology of acute self poisoning in the Western Province, Sri Lanka.
  • Epidemiology of acute self poisoning in the Tea Country Sri Lanka.
  • Respiratory Failure in Acute Organophosphate Poisoning.
  • Clinical, Electrophysiological and Biochemical correlates of Intermediate Syndrome (IMS) following Organophosphate (OP) Poisoning.
    Areas investigated
    1. Pathological mechanisms that occur at the neuromuscular junction following OP exposure.
    2. Develop neurophysiological parameters to predict the development of IMS.
    3. Develop a toxicokinetic and toxicodynamic model to predict IMS in OP poisoning.
    4. Develop clinical predictors for IMS/ late respiratory failure.
    5. Develop a pharmacokinetic/pharmacodynamic model to predict IMS with RBC acetylcholinesterase levels.
  • Electrophysiological Monitoring of the Effects of Pralidoxime in Organophosphate poisoning
    1. Neuromuscular function in OP poisoning.
    2. Effects of Pralidoxime on neuromuscular transmission failure.
  • Attention Deficit Hyperactivity Disorder (ADHD)
    Conducted at Lady Ridgeway Hospital (LRH), Sri Lanka.
    1. prevalence of ADHD in Sri Lanka
    2. severity of symptoms, Problems experienced by children with ADHD & their families after 6 weeks and 6 months of Methylphenidate.
    3. salivary cortisol level in ADHD children.

 

 

PUBLICATIONS


 

Reviews

 

  • Electrophysiological correlates of intermediate syndrome following acute organophosphate poisoning.
    Jayawardane P, Senanayake N, Dawson A.
    Clin Toxicol (Phila). 2009 Mar;47(3):193-205

 

 

Original Research Papers

 

  • Electrophysiological correlates of respiratory failure in acute organophosphate poisoning, evidence for differential roles of muscarinic and nicotinic stimulation
    Jayawardane P, Senanayake N , Buckley NA, Dawson AH
    Clin Toxicol (Phila). 2012 April;50(4): 250-253
  • The spectrum of intermediate syndrome following acute organophosphate poisoning: a prospective cohort study from Sri Lanka.
    Jayawardane P, Dawson AH, Weerasinghe V, Karalliedde L, Buckley NA, Senanayake N.
    PLoS Med. 2008 Jul 15;5(7):e147
  • Methylphenidate in children with attention deficit hyperactivity disorder: Experience from a Sri Lankan tertiary children's hospital.
    Sandya Himani Kariyawasam, Hemamali Perera, Anusha Koralagama, Pradeepa Jayawardane
    Journal of Child Neurology 2005; 20(6):496-499
  • A Descriptive study of attention deficit hyperactivity disorder (ADHD) at Lady Ridgeway Hospital for Children, Colombo
    S.H. Kariyawasam, A. Koralagama, P. Jayawardane, B. Karunathilake, V. Perera, H. Perera
    Sri Lanka Journal of Child Health, 2002; 31:109-114

 

 

Letters

 

  • Comment on late-onset intermediate syndrome due to organophosphate poisoning
    Pradeepa Jayawardane, Andrew Dawson
    Clin Toxicol (Phila). 2008 Nov;46(9):913
  • A comment on "Predicting outcome in acute organophosphorus poisoning with a poison severity score or the Glasgow Coma Scale"
    Pradeepa Jayawardane, Andrew Dawson
    QJM. 2008 Jun;101(6):507-8

 

 

Abstracts

 

  • Predictors of Intermediate syndrome following acute chlopyrifos poisoning
    Jayawardane P, Eyer P, Thiermann H, Senanayake N, Buckley N, Dawson A
    Clin Toxicol 2012:50(4):336
  • Electrophysiological correlates of respiratory failure in organophosphate poisoning, evidence for differential roles of muscarinic and nicotinic stimulation
    Jayawardane P, Senanayake N, Eyer P, Buckley N, Dawson A.
    Clin Toxicol 2009:47(5):486
  • Correlation between the neuromuscular transmission failure and the acetylcholine esterase in acute organophosphate poisoning
    Jayawardane P, Senanayake N, Eyer P, Buckley N, Dwson A.
    Clin Toxicol 2009:47(5):487
  • Serial repetitive nerve stimulation in organophosphorus poisoning provides clear evidence of two distinct pathophysiological processes in patients with intermediate syndrome
    Buckley NA, Dawson AH, Jayawardane P.
    Clin Toxicol 2009:47(5):506
  • Red blood cell acetylcholinesterase inhibition and intermediate syndrome
    Jayawardane P, Dawson A, Buckley NA, Senanayake N, Eyer P.
    Clin Toxicol 2008:46:398
  • Progression of electrophysiological abnormalities in acute organophosphate poisoning and the intermediate syndrome
    Jayawardane P, Dawson A, Senanayake N, Weerasinghe V, Buckley N.
    Clin Toxicol 2007:45:398
  • Effects of acute organophosphate poisoning on the neuromuscular junction
    Jayawardane P, Dawson A, Senanayake N, Weerasinghe V
    Ceylon Medical Journal 2007:52(suppl 1);12
  • Serial neurophysiological studies in 70 patients with organophosphate poisoning: early prediction of intermediate syndrome
    Jayawardane P, Dawson A, Senanayake N, Weerasinghe V
    Clin Toxicol 2006:44(5):729

 

 

COMMUNICATIONS


 

  • Use of carbapenems in Colombo South Teaching Hospital (CSTH) Kaluthanthiri D 1, Hiranthi HMH 1, Jayawardane P
    Poster presentation Scientific Sessions 2012,
    Faculty of Medical Sciences, University of Sri Jayewardenepura.
    December 6-7 2012, Colombo, Sri Lanka
  • Butyrylcholinesterase inhibition and the development of intermediate syndrome following acute organophosphate poisoning
    Jayawardane P, Eyer P, Thiermann H, Senanayake N, Buckley N, Dawson A
    Oral Presentation
    10th Annual Congress of Asia Pacific Association of Medical Toxicology,
    November 11-14 2011, Penang, Malaysia
  • Pattern of acute adult poisoning at a tertiary care hospital in the Western province Sri Lanka: A retrospective study
    Jayawardane P, Wijegoonawardene I, Kodikara T, Jayaratne SD
    Poster Presentation
    10th Annual Congress of Asia Pacific Association of Medical Toxicology,
    November 11-14 2011, Penang, Malaysia
  • Relationship between the serum chlorpyrifos level and the development of intermediate syndrome following acute organophosphate poisoning
    Jayawardane P, Eyer P, Senanayake N, Buckley N, Dawson A.
    Poster presentation
    7th Annual Congress of Asia Pacific Association of Medical Toxicology,
    December 7 -10 2008 Chandigar, India
  • Biochemical correlations of acute Chlorpyrifos poisoning
    Jayawardane P, Dawson A, Senanayake N, Weerasinghe V, Buckley N, Eyer P
    Oral presentation
    6th Annual Congress of Asia Pacific Association of Medical Toxicology,
    December 12-14 2007 Bangkok, Thailand
  • Electrophysiological monitoring of the effects of pralidoxime in acute organophosphate poisoning
    Jayawardane P, Dawson A, Buckley N, Senanayake N
    Poster presentation
    IX International Congress of Toxicology,
    July 15-19 2007, Montreal, Canada
  • Neurophysiological Monitoring of the effects of pralidoxime in acute organophosphate poisoning
    Poster presentation
    Jayawardane P, Dawson A, Buckley N, Senanayake N
    Annual Congress of Asia Pacific Association of Clinical toxicology
    Aug 6-9 2006, Colombo, Sri Lanka
  • Neurophysiological correlations in organophosphate poisoning
    Jayawardane P, Dawson A, Senanayake N, Weerasinghe V
    Annual Congress of Asia Pacific Association of Clinical toxicology
    Aug 6-9 2006, Colombo, Sri Lanka
  • Methylphenidate in children with ADHD: evidence from a Sri Lankan tertiary children's hospital
    S.H. Kariyawasam, H. Perera, A. Koralagama, P. Jayawardane
    Joint congress of International Child neurology Association and Asian and Oceanian Child Neurology Association 2002 Sept. Beijing, China
  • Is ADHD a problem in Sri Lanka?
    H. Kariyawasam, A. Koralagama, P. Jayawardane, B. Karunathilake, V. Perera, H. Perera
    Presented as the free paper 17 at 2001 Annual Academic Sessions of College of Paediatricians in Sri Lanka

 

 

AWARDS


 

  • National Science Foundation Travel Grant 2012
  • Asia Pacific Association of Medial Toxicology
    Travel award 2011
  • Richard and Sheila Peiris Memorial Award (CNAPT award)
    For the best research publication in medicine or in an allied field, published in the year 2008 Awarded by the Sri Lanka Medical Association
  • Presidential awards for Research 2009
    National Research Council, Sri Lanka
  • Young Investigator award 2009
    Awarded by European Association of Poison Centers and Clinical Toxicologists (EAPCCT) In 2009 May at Stockholm Sweden
  • Short listed for Young Investigator award 2008
    Awarded by European Association of Poison Centers and Clinical Toxicologists (EAPCCT)
  • Short listed for Young Investigator award 2007
    Awarded by European Association of Poison Centers and Clinical Toxicologists (EAPCCT)
  • International Congress of Toxicology Junior Fellowship
    Award 2007 Awarded by International Congress of Toxicology
  • National Science Foundation Travel Grant 2007
  • International Travel Award 2006
    Awarded by North American Academy of Clinical Toxicology (NAACT)
  • Presidential awards for Research 2005
    National Research Council, Sri Lanka