prof-neelika malavige

RESEARCH & PUBLICATIONS


 

Prof.  Neelika Malavige

Prof. Neelika Malavige MBBS (Col), MRCP (UK), DPhil (Oxon)

Professor in Microbiology
Department of Microbiology

Telephone - Office : +94 11 2758643     Mobile : +94 77 2443193
E-mail : neelikamalavige@ndm.ox.ac.uk


 

PRIZES AND AWARDS


 

  • 2017 - Oration and gold medal, Sri Lanka Medical Association
  • 2016 - Oration and gold medal, Allergy and Immunology Society Sri Lanka
  • 2015 - Vice Chancellors award for the best researcher in the University in year 2014
  • 2015 - Sri Lanka Presidential Research Awards
  • 2014 - P.B. Fernando oration and gold medal, Ceylon College of Physicians
  • 2014 - Zonta Woman of Achievement Award in the field of Medicine
  • 2014 - Sri Lanka Presidential Research Awards
  • 2013 - Sri Lanka Presidential Research Awards
  • 2012 - TWAS (Third World Academy of Science) young scientist award in Sri Lanka
  • 2012 - Sri Lanka Presidential Research Awards
  • 2011 - The Ten Outstanding Young Persons (TOYP) award for medical research
  • 2011 - S.C.Paul Oration and gold medal, Sri Lanka Medical Association
  • 2011 - Sri Lanka Presidential Research Awards
  • 2008 - CVCD Excellence award: most outstanding young researcher in medical sciences
  • 2008 - Sri Lanka Presidential Research Awards
  • 2007 - H.T.K.Fernando Award from Sri Lanka Medical Association
  • 2007 - Sri Lanka Presidential Research Awards
  • 2006 - Sri Lanka Presidential Research Awards
  • 2004 - Commonwealth Scholarship
  • 2004 - S.E. Seneviratne Award, Sri Lanka Medical Association
  • 2002 - Sri Lanka Presidential Research Awards
  • 2002 - Ganeshamoorthy award from College of Anaesthesiologists of Sri Lanka
  • 2000 - The Sir Andrew Caldecott gold medal for the best performance at the Final MBBS
  • 2000 - Joseph Nalliah Arumugam Memorial Award for the best performance at the final MBBS
  • 2000 - Dr. Alaric Jayasinghe Memorial Gold medal in Paediatrics
  • 2000 - Dr. M.V.P. Peris award for surgery- College of Surgeons of Sri Lanka
  • 2000 - Gold Medal on Anaesthesiology and Intensive Care, Sri Lanka College of Anaeshtesiologists

 

 

RESEARCH GRANTS RECEIVED


 

Funding Body Topic Amount
NIH, USA Investigation of the role of innate like lymphoid cells in acute dengue: Co-PI (2016-2018) US5,000
National Science Foundation Identification of the true burden and associated complications of dengue and related viral infections in Sri Lanka and finding long lasting solutions, through in depth understanding of the pathogenesis for development of therapeutic targets : PI (2017-2020) 20 million for 2017 (3,333)
National Science Foundation Investigation of functionality and phenotype of T cell responses in dengue infection (2016-2018) PI LKR 6.2 million
(,333.33)
National Science Foundation Validation of T cell based assay for determining past dengue serotype (2015-2017) PI LKR 4.76 million
($ 31,733.33)
National Research Council Investigation of the role of dengue NS1 in the pathogenesis of dengue (2015-2018) PI LKR 4.16 million
($ 27,733.33)
National Science Foundation Investigation of factors that lead to vascular leak in dengue. PI (2014-2016) PI LKR 4.1 million
($ 27,333.33)
National Science Foundation Determining correlates of a protective immune response in dengue infection. PI (2012-2014) LKR 5.37 million
($ 35,800)
International Society of Infectious Diseases Identification of a serum biomarker for predicting severe disease in patients with dengue infection. PI (2010-2012) $ 6000
National Research Council Sri Lanka Investigation of immune responses to the dengue virus. PI (2010-2013) LKR 1.29 million
National Science Foundation of Sri Lanka Identifying biomarkers for predicting severe disease in dengue infections. PI (2010-2012) LKR 1.3 million
University Research Grant Investigation of the role of Staphylococcus superantigens in the pathogenesis of atopic dermatitis (2010-2012) LKR 0.25 million
IRQUE University Grant Molecular characterization of the Varicella zoster virus LKR 0.15 million

 

 

PUBLICATIONS IN PEER REVIEWED JOURNALS


 

  1. Jayaratne E, Wijeratne D, Fernando S, Kamaladasa A, Gomes L, Wijewickrama A, Ogg GS, Malavige GN. Regulatory T cells in acute dengue viral infection. Immunology. 2017 Nov 15.
  2. Malavige GN, Ogg GS. Pathogenesis of vascular leak in dengue virus infection. Immunology. 2017 Apr 24
  3. Jeewandara, C., Gomes, L., Udari, S., Paranavitane, S.A., Shyamali, N.L.A., Ogg, G. S. and Malavige, G. N. Secretory Phospholipase A2 in acute dengue infection. 2016.
  4. Laxminarayan R, Kakkar M, Horby P, Malavige GN, Basnyat B. Emerging and re-emerging infectious disease threats in South Asia: status, vulnerability, preparedness, and outlook. BMJ. 2017 Apr 11;357:j1447. doi: 10.1136/bmj.j1447.
  5. Nadugala MN, Jeewandara C, Malavige GN, Premaratne PH, Goonasekara CL. Natural antibody responses to the capsid protein in sera of Dengue infected patients from Sri Lanka. PLoS One. 2017 Jun 5;12(6):e0178009
  6. Lohitharajah J, Malavige N, Arambepola C, Wanigasinghe J, Gamage R, Gunaratne P, Ratnayake P, Chang T. Viral aetiologies of acute encephalitis in a hospital-based South Asian population. BMC Infect Dis. 2017 Apr 24;17(1):303.
  7. Premaratne MK, Perera SS, Malavige GN, Jayasinghe S. Mathematical Modelling of Immune Parameters in the Evolution of Severe Dengue. Comput Math Methods Med. 2017;2017:2187390. doi: 10.1155/2017/2187390.
  8. Jayasundara SD, Perera SS, Malavige GN, Jayasinghe S. Mathematical modelling and a systems science approach to describe the role of cytokines in the evolution of severe dengue. BMC Syst Biol. 2017 Mar 11;11(1):34. doi: 10.1186/s12918-017-0415-3.
  9. Kamaladasa A, Gomes L, Jeewandara C, Shyamali NL, Ogg GS, Malavige GN. Lipopolysaccharide acts synergistically with the dengue virus to induce monocyte production of platelet activating factor and other inflammatory mediators. Antiviral Res. 2016 Jul 28;133:183-190.
  10. Kamaladasa A, Wickramasinghe N, Adikari TN, Gomes L, Shyamali NL, Salio M, Cerundolo V, Ogg GS,Malavige G.N. Expansion of highly activated iNKT cells with altered phenotype in acute dengue infection. Clin Exp Immunol. 2016 Feb 13. doi: 10.1111/cei.12778
  11. Jeewandara C, Gomes L, Paranavitane SA, Tantirimudalige M, Panapitiya SS, Jayewardene A, Fernando S, Fernando RH, Prathapan S, Ogg GS, Malavige GN. Change in Dengue and Japanese Encephalitis Seroprevalence Rates in Sri Lanka. PLoS One. 2015 Dec 22;10 (12):e0144799. doi: 10.1371/journal.pone.0144799. eCollection 2015
  12. Narmada Adikari T, Gomes L, Wickramasinghe N, Salimi M, Wijesiriwardana N, Kamaladasa A, Narangoda Liyanage AS, Ogg GS, Malavige GN. Dengue NS1 antigen contributes to disease severity by inducing IL-10 by monocytes. Clin Exp Immunol. 2015 Dec 1. doi: 10.1111/cei.12747
  13. Fernando S, Wijewickrama A, Gomes L, Punchihewa CT, Madusanka SD, Dissanayake H, Jeewandara C, Peiris H, Ogg GS, Malavige GN. Patterns and causes of liver involvement in acute dengue infection. BMC Infect Dis. 2016 Jul 8;16:319.
  14. Malavige G.N., Ogg G.S. Role of skin homing T cells in acute dengue infection. Annals of Translational Medicine. Ann Transl Med 2015;3(17):252. doi: 10.3978/j.issn.2305-5839.2015.09.12
  15. de Silva NR, Dasanayake WM, Karunatilleke C, Malavige GN. Food dependant exercise induced anaphylaxis a retrospective study from 2 allergy clinics in Colombo, Sri Lanka. Allergy Asthma Clin Immunol. 2015 Jul 25;11(1):22.
  16. Fernando AN, Malavige GN, Perera KL, Premawansa S, Ogg GS, De Silva AD. Polymorphisms of Transporter Associated with Antigen Presentation, Tumor Necrosis Factor-α and Interleukin-10 and their Implications for Protection and Susceptibility to Severe Forms of Dengue Fever in Patients in Sri Lanka. J Glob Infect Dis. 2015 Oct-Dec;7(4):157-64.
  17. Lohitharajah J, Malavige G.N., Chua A.J.S., Ng Mah Lee, Arambepola C, Chang T. Emergence of West Nile virus infections in Sri Lanka, BMC Infectious Diseases. BMC Infect Dis. 2015 Jul 31;15:305
  18. Jeewandara C, Adikari T.N., Gomes L, Fernando S., Fernando R.H., Perera M.K.T., Ariyarante D., Kamaladasa A, Salimi M, Prathapan S, Ogg G.S., Malavige G.N. Functionality of dengue virus specific memory T cell responses in individuals who were hospitalized or who had mild or subclinical dengue infection. PLoS Negl Trop Dis. 2015 Apr 13;9(4):e0003673
  19. Jeewandara C, Gomes L, Wickramasinghe N, Gutowska-Owsiak D, Waithe D, Paranavitane SA, Shyamali NL, Ogg GS, Malavige GN. Platelet activating activating factor contributes to vascular leak in acute dengue infection. PLoS Negl Trop Dis. 2015 Feb 3;9(2):e0003459. doi: 10.1371/journal.pntd.0003459. eCollection 2015.
  20. Gomes L, Fernando B.S.M, Fernando R.H., Wickramasinghe N, Shyamali N.L.A, Ogg G.S., Malavige G.N. Sphingosine 1-phosphate in acute dengue infection. PLOS one, 2014 Nov 19;9(11):e113394. doi: 10.1371/journal.pone.0113394
  21. Malavige GN, Ogg GS. T cell responses in Dengue virus infection. Journal of Clinical Virology. 2013 Oct 27. pii: S1386-6532(13)00471-X. doi:
  22. Senanayake MP, de Silva R, Jayamanna MD, Jayasinghe JA, Ratnayaka D, Jayasuriya V, Malavige GN. Identification of aero-allergen sensitization in children seeking treatment for bronchial asthma at a tertiary care hospital for children in Sri Lanka. Ceylon Med J. 2014 Sep;59(3):89-93.
  23. Malavige GN, Jeewandara C, Alles L, Salimi M, Gomes L, Kamaladasa, A, Jayaratne S, Ogg GS. Suppression of virus specific immune responses by IL-10 in acute dengue infection. PLOS Neglected Tropical diseases. PLOS Neglected Tropical diseases. 2013 Sep 5;7(9):e2409.
  24. Malavige GN, Gomes L, Alles L, Chang T, Salimi M, Fernando S, Nanayakkara KD, Jayaratne S, Ogg GS. Serum IL-10 as a marker of severe dengue infection. BMC Infect Dis. 2013 Jul 24;13(1):341.
  25. Lohitharajah J, Malavige GN, Wijewickrama A, Ambagawita A, Seneviratne AL, Ogg G. Molecular characterisation of varicella zoster virus genotypes in Sri Lanka. Ceylon Med J. 2013 Dec;58(4):153-6. doi: 10.4038/cmj.v58i4.6306.
  26. Malavige GN, Huang L-C, Salimi M, Gomes L, Jayaratne SD, et al. (2012) Cellular and Cytokine Correlates of Severe Dengue Infection. PLoS ONE 7(11): e50387. doi:10.1371/journal.pone.0050387
  27. Jayaratne SD, Atukorale V, Gomes L, Chang T, Wijesinghe T, Fernando S, Ogg GS, Malavige GN. Evaluation of the WHO revised criteria for classification of clinical disease severity in acute adult dengue infection. BMC Res Notes. 2012 Nov 20;5(1):645.
  28. Malavige GN, Ogg GS. Pathogenesis of severe dengue. Ceylon Med J. 2012 Sep;57(3):97-100. doi: 10.4038/cmj.v57i3.4701.
  29. Malavige G.N, , McGowan S, Atukorale V, Salimi M, Peelawatta M, Fernando N, Jayaratne S.D, Ogg G.S. Identification of serotype specific T cell responses to highly conserved regions of the dengue viruses. Clin Exp Immunol. 2012 May;168(2):215-23.
  30. Gomes PLR, Malavige GN, Fernando N, Mahendra MHR, Seneviratne JKK, et al. (2011) Superantigen Profile of Staphylococcus Aureus. Isolates from Patients with Atopic Dermatitis in Sri Lanka. J Clin Exp Dermatol Res 2:136.
  31. Malavige GN, Rostron T, Rohanachandra LT, Jayaratne SD, Fernando N, De Silva AD, Liyanage M, Ogg G. HLA Class I and Class II Associations in Dengue Viral Infections in a Sri Lankan Population. PLoS One. 2011;6(6):e20581. Epub 2011 Jun 9.
  32. Crack L.R., Jones L, Malavige G.N., Patel V, Ogg G.S. Human Anti-microbial Peptides LL-37 and Human β-defensin-2 reduce viral replication in varicella zoster virus infected keratinocytes. Clinical and Experimental Dermatology. 2012 Jul;37(5):534-43.
  33. Malavige GN, Fernando N, Ogg G. Pathogenesis of dengue viral infections. Sri Lanka Journal of Infectious Diseases. July, 2011
  34. Malavige G.N., Rohanachandra LT, Jones L, Crack L, Perera M, Fernando N, Guruge D, Ogg, G.S. IE63-specific T-cell responses associate with control of subclinical varicella zoster virus reactivation in individuals with malignancies. Br J Cancer. 2010 Jan 19.
  35. Gomes PL, Malavige GN, Fernando N, Mahendra MH, Kamaladasa SD, Seneviratne JK, Karunatilaka DH, Ogg GS. Characteristics of Staphylococcus aureus colonization in patients with atopic dermatitis in Sri Lanka. Clin Exp Dermatol. 2011 Mar;36(2):195-200. doi: 10.1111/j.1365-2230.2010.03962.x. Epub 2010 Nov 10.
  36. Malavige GN, Louise Jones, S.D. Kamaladasa, Ananda Wijewickrama, Suranjith L. Seneviratne, Antony P. Black, Graham S. Ogg. Natural killer cells during primary varicella zoster virus infection. Journal of Infection: 2010 Jul;61(2):190-2
  37. Jones L, Malavige GN, Jeffery K, Kemp E, Breuer J, Klenerman P, Ogg GS. Tracking epitope-specific antiviral CD4(+) T cell responses to a live attenuated vaccine reveals ongoing functional responses. Vaccine. 2009 Sep 8.
  38. Black AP, Jones L, Malavige GN, Ogg GS. Immune evasion during varicella zoster virus infection of keratinocytes. Clin Exp Dermatol. 2009 Jun 22.
  39. Malavige GN, Jones L, Kamaladasa SD, Wijewickrama A, Seneviratne SL, Black AP, Ogg GS. Viral load, clinical disease severity and cellular immune responses in primary varicella zoster virus infection in Sri Lanka. PLoS ONE. 2008;3(11):e3789. Epub 2008 Nov 21.
  40. Fernando S, Malavige GN, Karunaratne P, Palihawadana P, Vitarana T. Emerging infectious diseases, Journal of the National Science Foundation, Sri Lanka (in press)
  41. Malavige G.N., Jones L, Black A.P, Ogg, G.S.Varicella zoster virus glycoprotein E-specific CD4+ T cells show evidence of recent activation and effector differentiation, consistent with frequent exposure to replicative cycle antigens in healthy immune donors. Clin Exp Immunol. 2008 Jun; 152(3):522-31. Epub 2008 Mar 20
  42. Jones L, Black A.P, Malavige G.N., Ogg G.S. Phenotypic analysis of human CD4+ T cells specific for Immediate Early Protein IE63 of Varicella Zoster Virus. European Journal of Immunology; 2007 Dec.
  43. Malavige G.N, Rostron T, Seneviratne S.L, Fernando S, Sivayogan S, Wijewickrama A, Ogg G.S.HLA analysis of Sri Lankan Sinhalease predicts North Indian origin. International Journal of Immunogenetics. 2007 Oct;34(5):313-5
  44. Malavige G.N., Jones L, Black A.P., Ogg GS. Rapid effector function of varicella zoster virus glycoprotein I-specific CD4+ T cells many decades following primary infection. J Infect Dis. 2007 Mar 1;195(5):660-4. Epub 2007 Jan 22.
  45. Jones L, Black A.P, Malavige G.N., Ogg G.S. Persistent high frequencies of varicella zoster virus ORF4 protein specific CD4+ T cells following primary infection. J Virol. 2006 Oct;80(19):9772-8.
  46. Liyanage N.P.M ,Fernando S., Malavige G.N., Mallikahewa R., Sivayogan S., Jiffry M.T.M, Vitarana, Seroprevalence of Varicella Zoster Virus infections in the Colombo District. Indian Journal of Medical Sciences. Indian J Med Sci. 2007 Mar;61(3):128-34
  47. Malavige G.N. Ranatunga P.K., Jayaratne S.D., Wijesiriwardana B., Seneviratne S.L., Karunatilaka D.H. Dengue viral infections as a cause of encephalopathy. Indian J Med Microbiol. 2007 Apr;25(2):143-5
  48. Karunatilaka D.H. De Silva JR, Ranatunga PK, Gunasekara TM, Faizal MA, Malavige GN. Idiopathic purpura fulminans in dengue hemorrhagic fever. Indian J Med Sci. 2007 Aug;61(8):471-3
  49. Waduge TRW, Malavige GN, Pradeepan M, Wijeratne CN, Fernando S, Seneviratne S.L. Dengue infections during pregnancy: a case series from Sri Lanka and review of the literature. Journal of Clincal Virology. 2006 Sep;37(1):27-33. Epub 2006 Jul 13. Review.
  50. Malavige GN, Velathanthiri VG, Wijewickrama ES, Fernando S, Jayaratne SD, Aaskov J, Seneviratne SL. Patterns of disease among adults hospitalized with dengue infections. QJM. 2006 May;99(5):299-305. Epub 2006 Apr 7.
  51. Seneviratne SL, Malavige GN, de Silva HJ. Pathogenesis of liver involvement during dengue viral infections. Trans R Soc Trop Med Hyg. 2006 Jul;100(7):608-14. Epub 2006 Feb 17
  52. Malavige GN, Ranatunga PK, Velathanthiri VG, Fernando S, Karunatilaka DH, Aaskov J, Seneviratne SL. Patterns of disease in Sri Lankan dengue patients. Arch Dis Child. 2006 May;91(5):396-400. Epub 2006 Jan 31.
  53. Malavige GN, Fernando S, Fernando DJ, Seneviratne SL. Dengue viral infections. Postgrad Med J. 2004 Oct;80(948):588-601.
  54. Malavige G.N. de Alwis NM, Weerasooriya N, Fernando DJ. The validity of fasting blood glucose and post-prandial blood glucose measurement as an index of glycaemic control in Sri Lankan patients with type 2 diabetes. Ceylon Med J. 2006 Mar;51(1):40-1.
  55. Malavige GN. Does leptin restistance contribute to infections in patients with diabetes? Molecular pathology. 2003;56: 248
  56. Malavige GN. Chronic cough and tropical pulmonary eosinophilia. British Medical Journal 2003 May 10;326(7397):1036
  57. Malavige GN. Doctors, drug companies and Medical Ethics: A Sri Lankan perspective. Indian J Med Ethics. 2004 Jan-Mar;1(1):26.
  58. Malavige GN, de Alwis NM, Weerasooriya N, Fernando DJ, Siribaddanna SH. Increasing diabetes and vascular risk factors in a sub-urban Sri Lankan population. Diabetes Res Clin Pract 2002 Aug;57(2):143
  59. Malavige G.N, Fernando S, Aaskov J, Sivayogan S, Dissanayaka T, Peelawattage P, Dabare M. Seroprevalence of anti-dengue virus antibodies in children in the Colombo district. Dengue Bulletin 2006.
  60. Kularatne SA, G.N.Malavige, S.L.Seneviratne, V.G.N.S. Velathanthiri, P.K. Ranatunga, E.S. Wijewickrama, N.P. Gurugama, S.D. Jayaratne, D.H. Karunatilaka, J.G. Aaskov, S. Fernando et al. Recent studies on dengue in Sri Lanka. Dengue bulletin 2006.
  61. Velathathiri V.G.N.S. Fernando S, Fernando R, Malavige G.N., Peelawattage M, Aaskov J. Comparison of serology, virus isolation and RT-PCR in the diagnosis of dengue viral infections. Dengue Bulletin 2006.
  62. Somasundaram, G.N ; Malavige, G.N. ; Kamaladasa, S. Prevalence of hirsutism in Sri Lankan female university entrants. The Sri Lanka Journal of Dermatology. 2005. 16-17.
  63. Kamaladasa SD, Malavige GN, Fernando DJS. The Frequency of skin diseases in a diabetic clinic in Sri Lanka. Sri Lankan Journal of Dermatology. 2002; 6: 81-83
  64. Kamaladasa SD, Malavige GN, Ariyarathna CV. Prevalence of skin diseases among new entrants to the Medical Faculty. The Sri Lanka Journal of Dermatology. 2004
  65. Malavige GN. Platelets and dengue infection. Journal of the Sri Lanka College of Haematologists; Vol 3; Dec 2010. 24-28
  66. Malavige GN. The use of papaya (Carica papaya) leaf juice in the treatment of thrombocytopenia. Journal of the Sri Lanka College of Haematologists; Vol 3; Dec 2010. 40-41

 

 

AREAS OF INTEREST


 

My areas of interests: Pathogenesis of vascular leak in dengue, Correlates of a protective immune response, microbiome.